Egger Gerd Homepage

 

Dr. med. Gerd Egger

former Professor of Pathophysiology at the Institute of Pathophysiology / Medical University Graz Austria
born 1939, retired since October 2004

Address: Kapellenweg 16, A 8063 Hart-Purgstall, Austria
               E-Mail: egger.gerd@aon.at

Research fields: inflammation, neutrophil granulocyte, polymorphonuclear leukocyte (PMN), PMN functions, 
                           clinical measurement of PMN functions, migration, ROS release, actin cytoskeleton
                           infection risk in immunocompromised patients, multiple trauma, severe trauma, 
                           surgical trauma, shock, organ transplantation

 

 

PUBLIKATIONSLISTE GRANULOCYTENFUNKTIONEN
Granulocyte functions, list of publications


ORIGINALARBEITEN – original articles

 

Egger G. A noninvasive membrane filter method for in vivo determination of leukocyte migration in man. Inflammation 1980, 4: 215-231

 

Egger G, Klemt C, Spendel S, Kaulfersch W, Kenzian H. Migratory activity of blood polymorphnuclear leukocytes during juvenile rheumatoid arthritis, demonstrated with a new whole-blood membrane filter assay. Inflammation 1994,18: 427-441

 

Hofer HP, Kukovetz E, Egger G, .Wildburger R, Quehenberger F, Schaur RJ. Polymorphnuclear leucocyte migration response in uneventful wound healing following trauma surgery. Arch Orthop Trauma Surg 1994, 113: 170-173

 

Hofer HP, Egger G, Bratschitsch G, Kukovetz EM, Petek W, Schaur RJ. Phagocyte activation and its implication in wound healing following trauma surgery. Med Sc Res  1994; 22: 533-534

 

Hofer HP, Bratschitsch G, Egger G, Kukovetz E, Khoschsorur GA, Schweighofer F, Schaur RJ. Postsurgical assessment of the acute inflammatory response within healing wounds. Brit J Surg 1994; 8: Suppl 1, p 93

 

Hofer HP, Kukovetz E, Egger G, Khoschsorur GA, Wildburger R, Petek W, Schaur RJ. PMN-related parameters for the monitoring of wound healing in traumatology. Eur J Orthop Surg Traumatol 1995; 5: 21-26

 

Hofer HP, Egger G, Kukovetz E, Petek W, Schaur RJ. Neutrophil migration activity (NMA) A new migration test for the monitoring of wound healing in traumatology? Eur.J.Orthop.Traumatol. 1995; 5: 143-145

 

Kukovetz E, Hofer HP, Egger G, Khoschsorur GA, Bratschitsch G, Petek W, Quehenberger F, Schaur RJ. Assay of phagocyte activation by means of malondialdehyde and luminol-enhanced chemiluminiscence during uneventful wound healing following trauma surgery. Redox Report 1995; 1: 247-254

 

Egger G., Aglas F, Rainer F. Blood polymorphnuclear leukocyte migratory activities during rheumatoid arthritis. Inflammation 1995; 19: 651-667

 

Kukovetz E, Bratschitsch G., Hofer HP, Egger G, Steindorfer P, Schaur RJ. Case report. Post-surgical wound infection monitored by a new polymorphnuclear leucocyte migration test. Med Sci Res 1995; 23: 791-792

 

Hofer HP, Egger G, Kukovetz E, Bratschitsch G, Steindorfer P, Schaur RJ. The influence of trauma on changes in neutrophil granulocyte function assessed by an analysis of granulocyte migration. Langenbecks Arch Chir 1996; 38:148-154

 

Egger G, Allmayer T, Iberer F, Tcheliessnigg KH, Auer T, Wasler A, Petutschnigg B. Impaired polymorphnuclear leucocyte migration as a possible monitor for the risk of septicaemia in immunosuppressed transplant patients. Med Sci Res 1996; 24: 17-19

 

Hofer HP, Bratschitsch G, Kukovetz E, Egger G, Schweighofer F, Schaur RJ. Einfluß des Traumas auf Phagocytenaktivierung quantifiziert durch Chemiluminiszenzanalyse und einen neuen Granulocyztenmigrationstest. Unfallchirurg 1996; 257: 243-249

 

Hofer HP, Kukovetz E, Bratschitsch G, Egger G, Aigner R, Schaur RJ. Die Frühdiagnose des frühen Infekts an Knochen,Gelenken und Weichteilen. Akt.Traumatol. 1996; 26: 224-232

 

Kukovetz EM, Bratschitsch G, Hofer HP, Egger G, Schaur RJ. Influence of age on the release of reactive oxygen species by phagocytes as measured by a whole blood chemiluminescence assay. Free Radicals Biol Med 1996; 22: 433-438

 

Egger G, Kukovetz EM, Hayn M, Fabjan JS. Changes in the polymorphnuclear leukocyte function of blood samples induced by storage time, temperature and agitation. Immunol Meth 1997; 206: 61-71

 

Bratschitsch G, Hofer HP, Kukovetz E, Egger G, Schweighofer F, Schaur RJ. Der Stellenwert von Entzündungsparametern zur Wundheilungskontrolle nach unfallchirurgischen Eingriffen. Acta Chir Austriaca 1997; Suppl 133: 38-40

 

Aglas F, Rainer F, Lipp RW, Schnedl WJ, Horn S, Egger G. Effect of steroid treatment on the migration behaviour of neutrophils in patients with early rheumatoid arthritis. Rheumatol Int 1997; 17: 137-140

 

Aglas F, Hermann J, Egger G. Abnormal directed migration of blood polymorphonuclear leukocytes in rheumatoid arthritis. Potential role in increased susceptibility to bacterial infections. Mediat Inflamm 1998; 7: 19-23

 

Egger G, Burda A, Hengster P, Kunc M, Margreiter R. Polymorphonuclear leukocyte functions as predictive markers for infections after organ transplantation. Transpl Intern 2000; 13: 114-121

 

Egger G, Burda A, Glasner A. A simple method for measuring the F-actin content of human polymorphonuclear leukocytes in whole blood. Virchows Arch 2001; 483: 394-397

 

Egger G, Burda A, Obernosterer A, Mitterhammer H, Kager G, Jürgens G, Hofer HP, Fabian J, Pilger E. Blood polymorphonuclear leukocyte activation in atherosclerosis. Effects of aspirin. Inflammation 2001; 25: 129-135

 

Glasner A, Egger G, Winter R. Impaired whole-blood polymorphonuclear leukocyte migration as a possible predictive marker for infections in premature preterm rupture of membranes. Inf Diseas Obstet Gynecol 2001; 12: 1-6

 

Egger G, Burda A, Mitterhammer H, Baumann G, Bratschitsch G, Glasner A. Impaired blood polymorphonuclear leukocyte migration and infection risk in severe trauma.  J Infection 2003; 47: 148-154

 

Egger G, Aigner R, Glasner A, Hofer HP, Mitterhammer H, Zelzer S. Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters. Intensive Care Med 2003; 30: 331-334

 

Giuliani A, Mitterhammer H, Burda A, Egger G, Glasner A. Polymorphonuclear leukocyte function during the menstrual cycle and during controlled ovarian hyperstimulation. Fertil Steril 2004; 82:1711-1713

 

El-Shabrawi Y, Walch A, Hermann J, Egger G, Foster CS. Inhibition of MMP-dependent chemotaxis and amelioration of experimental autoimmune uveitis with a selective metalloproteinase-2 and -9 inhibitor. J Neuroimmunol 2004; 155: 13-20

 

Egger G, Mitterhammer H, Smolle KH. Blood polymorphonuclear keukocyte migration – a diagnostic tool for monitoring infection risk and course of infection in severe trauma and shock. Current Trends Immunol 2004, Vol.6, 149-176

 

 

BÜCHER – books

 

Egger G. Die Akute Entzündung. Grundlagen, Pathophysiologie und klinische Erscheinungsbilder der Unspezifischen Immunität. Springer Wien New York 2005.

 

 

KONGRESSBEITRÄGE – congress presentations

 

Egger G. Priming of polymorphnuclear leukocytes (PMN) by cytokines demonstrated with a new whole-blood membrane filter migration assay. International Congress on Inflammation ICOI, Rom, 1991

 

Egger G, Klemt C, Kaulfersch W, Spendel S. A new PMN migration test for a therapy control of  juvenile rheumatoid arthritis (JRA). International Congress on Inflammation ICOI, Rom, 1991

 

Kaulfersch W, Egger G, Ioannou A, Klemt C, Mangge H, Spendl S. Leukocyten-Migrationstest zur Therapiekontrolle bei Patienten mit Juveniler Rheumatoider Arthritis. 29. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde, Graz, 1991

 

Allmayer T, Iberer F, Egger G, Sabin K, Tscheliessnigg KH, Auer T, Wasler A, Petutschnigg B. Leukozytenmigrationstest als Transplantations-Monitoring? Erste Ergebnisse nach oHTX. Österreichische Gesellschaft für Transplantation, Transfusion und Genetik, Jahrestagung, Gosau, 1992

 

Egger G, Allmayer T, Iberer F, Sabin K, Tscheliessnigg KH, Auer T, Wasler A, Petutschnigg B. A new PMN migration assay for monitoring immune suppression therapy after orthotopic heart transplantation. 5th INWIN 93, Interscience World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators, Genf, 1993

 

Hofer HP, Kukovetz E, Egger G, Wildburger R, Petek W, Schaur RJ. PMN migration test - a new marker in wound healing monitoring after elective traumatological-orthopedic surgery. Highlights in Bone Pathophysiology Orthopaedic Surgery Endoprosthetics. Prag, 1993

 

Hofer HP, Kukovetz E, Egger G, Petek W, Schaur RJ, Bratschitsch G, Koschsorur GA, Schweighofer F, Wildburger R. Neue Aspekte in der Wundheilungsverlaufkontrolle. Acta Chirurgica austriaca, Suppl.106. 25.Jahrestagung der Österreichischen Gesellschaft für Osteosynthesefragen, Graz, 1994

 

Bratschitsch G, Hofer HP, Egger G, Kukovetz E, Koschsorur GA, Schweighofer F, Wildburger R, Schaur RJ. Chemiluminiscence-assisted monitoring of the inflammatory response after trauma surgery. International Conference on Clinical Chemiluminiscence, Berlin, 1994

 

Bratschitsch G., Kukovetz E, Hofer HP, Egger G, Steindorfer P, Schaur RJ. Is neutrophil migratory activity (NMA) a reliable marker for the monitoring of wound healing in traumatology? Tagung der Österreichischen Biochemischen Gesellschaft, Graz, 1995

 

Kukovetz E, Bratschitsch G, Hofer HP, Egger G, Steindorfer P, Schaur RJ. Influence of age on phagocyte activation by a whole blood chemiluminescence assay. Tagung der Österreichischen Biochemischen Gesellschaft, Graz, 1995

 

Hofer HP, Egger G., Bratschitsch G., Khoschsorur GA, Schaur RJ. Verhaltenscharakteristika verschiedener Entzündungsparameter nach unfallchirurgischen Eingriffen. Swiss Surgery Suppl 1996; 2: 86

 

Bratschitsch G, Kukovetz E, Hofer HP, Egger G, Petek W, Schweighofer F, Schaur RJ. Phagocyte activation following monotrauma surgery - clinical aspects. Eur J Haematol 1996; Suppl. 59, Vol 57: 56

 

Egger G, Kukovetz E, Allmayer T, Tscheliessnigg KH, Iberer F, Bratschitsch G, Hofer HP. A whole-blood polymorphnuclear leukocyte(PMN) migration test for monitoring infection risk in immunosuppressed patients. Eur J Haematol 1996; 59, Vol 57: 24

 

Hauser H, Kukovetz E, Steindorfer P, Egger G, Bratschitsch G, Thalhammer M, Klimpfinger M, Uranüs S. Evaluierung des Stellenwertes von Chemiluminiszenz-Analyse und Elastasebestimmung im klinischen Infektmonitoring am Beispiel der Appendicitis acuta. 37.Tagung der Österreichischen Gesellschaft für Chirurgie, Graz, 1996

 

Schaur RJ, Kukovetz E, Bratschitsch G, Hofer HP, Egger G. Oxidative stress and aging: the role of phagocytes. SFRR Europe Summer Meeting, Abano Therme 1997

 

Kukovetz EM, Bratschitsch G, Hofer HP, Egger G, Steindorfer P, Schaur RJ. Characteristics of the chemiluminescence response of circulating blood phagocytes: correlation with age. Seggauer Workshop 1997. BioFactors 1997; 6: 251-252

 

Bratschitsch G, Kukovetz EM, Hauser H, Egger G, Thalhammer M, Klimpfinger M, Steindorfer P, Schaur RJ. Luminol-enhanced whole blood chemiluminescence in a human inflammation model: patients with suspected appendicitis acuta. Seggauer Workshop 1997. BioFactors 1997; 6: 221-222

 

Lauda PH, Hofer HP, Egger G, Fabjan J, Kukovetz E, Bratschitsch G, Schaur RJ. Post-surgical assessment of the acute inflammatory response by polymorphonuclear leucocyte (PMN) functional parameters and acute phase reactants blood levels. PGA 51 Meeting, P-9102. New York State Society of Anesthesiologists, New York 1997.

 

Egger G, Lippitsch M, Kieslinger D. Whole-blood polymorphnuclear leukocyte (PMN) migration evaluated in an automated image analyzer. 13th International Congress of Cytology, Tokyo 1998. Acta Cytologica 42/2 (suppl): 472

 

Hofer HP, Egger G, Bratschitsch G, Kukovetz E, Schaur RJ. Trauma causes differential alterations of polymorphonuclear leukocyte (PMN) activation and acute phase reactants blood levels in a human inflammation model. 3rd European Traumatology Congress, Amsterdam 1998

 

Hengster P, Egger G, Burda A, Kunc ML, Margreiter R. Erste Ergebnisse mit der Bestimmung von Markern des unspezifischen Abwehrsystems zur Erfassung des Infektionsrisikos nach Organtransplantationen. 12. Jahrestagung der Österreichischen Gesellschaft für Transplantation, Transfusion und Genetik, Bad Tatzmannsdorf 1998

 

Egger G, Burda A, Hengster P, Kunc M, Margreiter R. Definition of the sepsis risk in transplant patients by polymorphonuclear leukocyte function tests. 17th European Congress of Pathology and XIX Spanish Congress of Pathology Barcelona 1999. Virchows Archiv 436/3: 321

 

Burda A, Egger G, Glasner A. The actual actin polymerization degree and reactivity in clinical diagnostic, demonstrated in whole blood with a new method. 17th European Congress of Pathology and XIX Spanish Congress of Pathology Barcelona 1999. Virchows Archiv 436/3: 344

 

Hofer HP, Egger G, Bratschitsch G, Schaur RJ. Trauma causes differential alterations of       polymorphonuclear leukocyte (PMN) activation and acute phase reactants blood levels in         a human inflammation model. 5th World Congress on Shock, Inflammation and Sepsis. Munich 2000

 

Hengster P, Mark W, Margreiter R, Egger G. Impaired granulocyte function precedes infection in immuno-compromised allograft recipients. 11th International symposium on Bioluminescence and Chemiluminescence, Proc Biolum Chemilum 2000: 403-406

 

Glasner A, Karpf E, Mitterhammer H, Egger G, Winter R. Impaired whole-blood polymorphonuclear leukocyte migration and increased reactive oxygen species release as an early indicator for chorioamnionitis in patients with pretem premature rupture of membranes and glucocorticoid administration? 17th European congress of Obstetrics and Gynaecology Prague 2002. Ceska Gynekologie Supplementum 2 : 88

 

Smolle KH, Mitterhammer H, Kaufmann P, Wonisch W, Aigner R, Egger G. Impaired blood PMN migration as an indicator of increased susceptibility for bacterial infections in critically ill patients. 23rd International Symposium on Intensive Care and Emergency Medicine. Brussels 2003. Critical Care 7, Suppl.2: P37

 

Mitterhammer H, Smolle KH, Kaufmann P, Wonisch W, Aigner R, Egger G. Impaired PMN migratory capacity: a risk marker for impending infections in severe trauma patients. 23rd International Symposium on Intensive Care and Emergency Medicine. Brussels 2003. Critical Care7, Suppl.2: P38

 

Mitterhammer H, Smolle KH, Kaufmann P, Aigner R. Impaired migration in parallel with high reactive oxygen species (ROS) production of blood polymorphonuclear leukocytes (PMN) precedes severe infections in critically ill patients. First International Congress “Sepsis and Multiorgan Dysfunction”, Weimar, Germany 2003. Infection 2003; 31: 271

 

Smolle KH, Mitterhammer H, Kaufmann P, Wonisch W, Egger G. Minimizing the size of blood samples and the expenditure of work in inflammation diagnosis. First International Congress “Sepsis and Multiorgan Dysfunction”, Weimar, Germany 2003. Infection 2003; 31: 275

 

Mitterhammer H, Strunk D, Neumeister P, Wölfler A, Glasner A, Egger G. Polymorphonuclear leukocyte migratory capacity in patients with NHL and AML. XVIIth Meeting of the International Society of Haematology, Graz, Austria 2003, abstract O62

 

Mitterhammer H, Smolle KH, Kaufmann P, Aigner R, Wonisch W, Egger G. Predictive markers for nosocomial infections in multiple trauma: Comparison of thirteen inflammation parameters. 24th International Symposium on Intensive Care and Emergency Medicine, Brussels 2004. Critical Care Vol.8, Suppl.1, 93 P188

 

Baumann G, Egger G, Mitterhammer H, Baumann A. Impaired blood PMN migration – a new marker for infection risk in patients with severe trauma. American society of Critical Care Anesthesiologists (ASCCA). 17th annual meeting, Las Vegas, Nevada, October 22, 2004

 

 

PUBLIKATIONSLISTE  AKUTE ENTZÜNDUNG - TIERVERSUCH

Acute inflammation - animal trials, list of  publications

 

ORIGINALARBEITEN – original articles

 

Egger G, Porta S. The influence of a permanent Isoproterenol (ISO) application on the dynamics of the Sephadex inflammation. Exp Path 1979; 17: 12-17

 

Egger G, Porta S, Gollmann D. Antiinflammatory substances appearing during an acute inflammation and the alteration of their properties by Isoproterenol (ISO). An in vivo investigations in rats. Exp Path 1979; 17: 327-333

 

Egger G. In vivo demonstration of endogenous substances regulating the regression of the acute inflammation. Exp Path 1981; 20:175-181

 

Egger G. Modifications in the regression of the acute inflammation caused by a β-adrenergic effect unbalanced by the α-component (“biased β-effect”). Exp Path 1982; 21: 149-155

 

Egger G, Sadjak A, Porta S, Pürstner P, Gleispach H. Changes in blood catecholamines, insulin, corticosterone and glucose during the course of the Sephadex inflammation. Exp Path 1982; 21: 215-219

 

 Egger G, Porta S, Gollmann D. Neutrophil aggregation during migration in vivo. Inflammation 1982; 6: 147-159

 

Egger G, Korsatko W, Porta S. The long-term influence of Isoproterenol (ISO) retard tablets on the course of an acute inflammation. Exp Path 1984; 25: 107-114

 

Egger G. Differences in the inflammatory reaction of contralateral sites of the body to equivalent noxae. Z Versuchstierk 1984; 26: 43-47

 

Fischer G, Yanik M, Schober A, Egger G. Influence of a weak magnetic field on the development of an acute inflammation in rats. Zbl Bact Hyg, I Abt Orig B 1984; 179: 32-43

 

Tögl-Leimüller A, Egger G, Porta S. Albumin as a one-way transport vehicle into sites of inflammation. Exp Pathol 1986; 30: 91-96

 

Egger G, Sadjak A, Porta S, Supanz S, Pürstner P. Laboratory handling and its influence on hormonal and metabolic parameters during acute inflammation in rats. A critique of long-term treatment by repeated injections. Horm Metabol Res 1986; 18: 746-749

 

Egger G, Macheiner U. The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in acute inflammation generation, demonstrated with the Sephadex model in rats. Exp Pathol 1987; 31: 39-46

 

Egger G, Spendel S, Porta S. Characteristics of ingress and life span of neutrophils at a site of acute inflammation, determined with the Sephadex model in rats. Exp Pathol 1988; 35: 209-218

 

Stelmaszynska T, Kukovetz E, Egger G, Schaur RJ. Possible involvement of myeloperoxydase in lipid peroxidation. Int J Biochem 1992; 24: 121-128

 

Schaur RJ, Dussing G, Kink E, Schauenstein E, Posch W, Kukovetz E, Egger G. The lipid peroxidation product 4-hydroxynonenal is formed  by – and is able to attract – rat neutrophils in vivo. Free Rad Res 1994; 20: 365-373

 

 

PATENTE – PATENTS

 

Österreichische Patente – Austrian Patents

Nr. 394455

Nr. 406310

 

US Patent

Nr. 6350610 B2

 

Europäische Patentanmeldung

European Patent Application

Nr. 99927575.3-2404